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Randomisation of new participants to the RAMPART trial will end on Friday 30th June 2023.

A trial has shown that starting treatment with a new immunotherapy drug called pembrolizumab shortly after kidney cancer has been removed by surgery, reduces the risk of cancer coming back in some patients.  Pembrolizumab has therefore been approved in some regions of the world for some patients who have had their kidney cancer removed. Many of the people who would be eligible for RAMPART are now eligible to receive pembrolizumab.  

Over the coming months, pembrolizumab is likely to become more widely available across the world. For this reason, our pharmaceutical partner (AstraZeneca) has requested that we stop recruiting to RAMPART earlier than originally planned.

The decision to stop randomising new participants has not been made because of any safety concerns about the treatments we are investigating in the RAMPART trial.


I am already a participant on the trial – what does this mean for me?

If you are already participating in RAMPART, nothing will change for you with regards to your trial experience.

If you are currently receiving treatment within the trial, you will continue to receive it for up to 12 months.

If you were allocated to the control arm (active monitoring), or if you have completed your protocol treatment you will continue to be followed up and will be invited to CT scans and follow-up appointments as before.

Continuing to take part in your RAMPART follow-up is important. We will learn more about immunotherapy and potential treatments for kidney cancer from the information you provide us.

If you have any queries about participating in RAMPART or any of the information in this update, please speak to your RAMPART study doctor.

The RAMPART team wish to thank you for your continued participation.

How Can I Participate?

If you are interested in taking part in the RAMPART trial, please talk to your doctor in the first instance. You will need to attend your local RAMPART site (please refer to the site map) and your doctor can arrange an appointment for you to meet with the local team. They will provide you with more information about the trial and can answer any questions you have. If you are still happy to proceed, they will then complete some checks to confirm whether you are suitable for the trial.