Trial Committees
Trial Management Group (TMG)
The Trial Management Group (TMG) comprises the Chief Investigators, all trial chiefinvestigators, other co-investigators (clinical and non-clinical), members with specific interests (e.g. pharmacist, nurse, user representative) and members of the MRC CTU. The TMG is responsible for the day-to-day running and management of the trial. It holds regular teleconferences and face-to-face meetings.
TMG members include the Chief Investigator, other co-investigators and members of the MRC CTU. The TMG advises on the promotion, running and safety concerns of the trial through regularly held meetings.
Independent Trial Steering Committee (TSC)
The Trial Steering Committee (TSC) has membership from the senior members of the TMG and representatives of the funder plus independent members, including the Chair. The role of the TSC is to provide overall supervision for the trial and provide advice through its independent Chair. The ultimate decision for the continuation of the trial lies with the TSC.
The RAMPART Trial Steering Committee (TSC) is the executive committee for the trial. It is made up of members who are independent of RAMPART trial investigators and the MRC CTU, whilst also including CTU staff working on the trial. The role of the TSC is to provide overall supervision for the trial. The ultimate decision for the continuation of the trial lies with the TSC.
Independent Data Monitoring Committee (IDMC)
An Independent Data Monitoring Committee (IDMC) has been formed. The IDMC will be the only group who see the confidential, accumulating data for the trial. Reports to the IDMC are produced by the MRC CTU statisticians. The IDMC will consider data using the pre-agreed statistical analysis plan and will advise the TSC. The IDMC can recommend premature closure or reporting of the trials or discontinuation of recruitment to any research arm.
The RAMPART Independent Data Monitoring Committee (IDMC) is independent of RAMPART investigators and the MRC CTU. The IDMC will be the only group who sees the confidential, accmulating data for the trial separately by randomised group.
Trial Management Group (TMG)
| Member | Role |
| James Larkin | Chief Investigator |
| Prof Tom Powles | Investigator |
| Dr Laurence Albiges | Investigator |
| Dr Toni Choueiri | Investigator |
| Prof Ian Davis | Investigator |
| Prof David Harrison | Investigator |
| Dr Paul Nathan | Investigator |
| Prof Brian Rini | Investigator |
| Mr Alastair Ritchie | Investigator |
| Dr Grant Stewart | Investigator |
| Prof Martin Stockler | Investigator |
| Dr Derfel Ap Dafydd | Radiologist |
| Ms Anita McWhirter | Pharmacist |
| Ms Sarah Scovell | Research Nurse |
| Dr Pat Hanlon | Consumer Representative |
| Ms Christy Watson | Consumer Representative |
| Margot Gorzeman | International Collaborator |
| CTU | |
| Dr Angela Meade | UCL Principal Investigator |
| Prof Rick Kaplan | Clinical Oncologist |
| Mr Ben Smith | Trial Manager |
| Miss Hanna Bryant | Trial Manager |
| Dr Francesca Schiavone | Trial Manager |
| Mr Nat Thorogood | Data Manager |
| Mr Kalam Hussain | Data Manager |
| Dr Louise Choo | Statistician |
| Ms Rahela Choudhury | Clinical Project Manager |
| Prof Max Parmar | Senior Statistician |
Site Evaluation Committee
Members of the TMG sit on this committee as required.